active rheb-gtp [26910]
[30 µl]
catalog number:  26910
gene symbol:  rheb
description:   anti-active rheb mouse monoclonal antibody
background:   small gtpases are a super-family of cellular signaling regulators. rheb is a member of the ras-superfamily gtpases. rheb has been shown to interact with c-raf, mammalian target of rapamycin (mtor), tsc2, ataxia telangiectasia mutated (atm), kiaa1303 and ataxia telangiectasia and rad3 related (atr).
immunogen:   recombinant full length protein of active rheb.
applications:   ip, ihc
recommended dilutions:   1 μg for 1~2 mg total cellular proteins for ip
1:100 dilution for ihc
concentration:   1 mg/ml
host:   mouse
format:   liquid
clonality:   monoclonal
isotype:   igm
purity:   purified from ascites
storage buffer:
preservative:  no
constituents:  pbs (without mg2+ and ca2+), ph 7.4, 150 mm nacl, 50% glycerol
species reactivity:  anti-active rheb antibody recognizes active rheb of vertebrates.
storage conditions:  store at -20°c. avoid freeze / thaw cycles
immunoprecipitation/western blot:  
rheb activation assay. purified rheb proteins were immunoprecipitated after treated with gdp (lane 1) or gtpγs (lane 2). immunoprecipitation was done with the anti-active rheb monoclonal antibody (cat. no. 26910). immunoblot was with an anti-rheb rabbit polyclonal antibody (cat. no. 21098).
publications:
1.  
    cancer res. 2014 feb 15;74(4):1067-78
2.  
    plos one. 2013 dec 31;8(12):e83941

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